BDBM50576479 CHEMBL4878465

SMILES COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N1CCC(CC1)C(O)=O

InChI Key InChIKey=GUVGQRABQXNJRS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50576479   

TargetCyclin-dependent kinase 9(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50576479(CHEMBL4878465)
Affinity DataIC50: 120nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate measured after 1.5 hrs by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50576479(CHEMBL4878465)
Affinity DataIC50: 680nMAssay Description:Inhibition of CDK9 in human A-431 cells assessed as reduction in RNA polymerase2 phosphorylation at C-terminal ser2 residue incubated for 4 hrs by In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed