BDBM50576250 CHEMBL4869752

SMILES CCOc1cc(NC(=O)NCc2cc(C)c(Nc3cn(C)nc3C)cn2)cc(n1)C(F)(F)F

InChI Key InChIKey=JZXDEGLEWCFEOC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50576250   

TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576250(CHEMBL4869752)
Affinity DataIC50: 55nMAssay Description:Antagonist activity at recombinant human S1P2 receptor in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576250(CHEMBL4869752)
Affinity DataIC50: 55nMAssay Description:Antagonist activity at recombinant human S1P2 receptor expressed in human CHO cells assessed as EC80 S1P-induced activation incubated for 4 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576250(CHEMBL4869752)
Affinity DataIC50: 4.80E+3nMAssay Description:Agonist activity at human S1P2 receptor expressed in CHO cells assessed as calcium flux measured for 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576250(CHEMBL4869752)
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as EC80 S1P-induced calcium flux measured for 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed