BDBM50576249 CHEMBL4845783

SMILES CCOc1cc(NC(=O)NCc2cc(C)c(cn2)-c2cn(C)nc2C(F)(F)F)cc(Cl)n1

InChI Key InChIKey=LFUJDODKDQAKJC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50576249   

TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576249(CHEMBL4845783)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at recombinant human S1P2 receptor in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576249(CHEMBL4845783)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at recombinant human S1P2 receptor expressed in human CHO cells assessed as EC80 S1P-induced activation incubated for 4 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576249(CHEMBL4845783)
Affinity DataIC50: 4.40E+3nMAssay Description:Agonist activity at human S1P2 receptor expressed in CHO cells assessed as calcium flux measured for 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576249(CHEMBL4845783)
Affinity DataIC50: 1.10E+4nMAssay Description:Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as EC80 S1P-induced calcium flux measured for 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed