BDBM50575718 CHEMBL4873384

SMILES Clc1cc(Cl)cc(c1)N1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O

InChI Key InChIKey=YINSFKOGVSNIAY-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50575718   

TargetCathepsin D(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 6.08E+3nMAssay Description:Inhibition of MMP-12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MMP-8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMatrilysin(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MMP-7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of DPP-IV (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 173nMAssay Description:Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCaspase-3(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Caspase 3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of ADAM-10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 8.45E+3nMAssay Description:Inhibition of ADAM-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of human recombinant TACE (AA34 to 660) assessed as cleavage of fluorescent substrate using 5FAM-LAQAVRSSSRK-5TAMRA as substrate by bioche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP14 (AA112 to 298) assessed as cleavage of fluorescent substrate using 390 MMP FRET as substrate incubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP2 (AA34 to 660) assessed as cleavage of fluorescent substrate using 390 MMP FRET as substrate incubated for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 448nMAssay Description:Inhibition of human recombinant ADAMTS-4 (AA1 to 520) assessed as cleavage of fluorescent substrate using as TBIS-1 substrate incubated for 180 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed