BDBM50575492 CHEMBL4784496

SMILES [H][C@]12CC[C@]([H])(C[C@@H](C1)NC(C)=O)N2Cc1ccc(Oc2nc3ncccc3s2)cc1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50575492   

TargetLeukotriene A-4 hydrolase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50575492(CHEMBL4784496)
Affinity DataIC50: 48nMAssay Description:Inhibition of LTA4H in human whole blood assessed as reduction of calcium ionophore A23187-stimulated LTB4 generation preincubated for 4 hrs followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50575492(CHEMBL4784496)
Affinity DataIC50: 18nMAssay Description:Inhibition of LTA4H in human PBMC assessed as reduction of calcium ionophore A23187-stimulated LTB4 generation preincubated for 4 hrs followed by ion...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50575492(CHEMBL4784496)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50575492(CHEMBL4784496)
Affinity DataIC50: 3nMAssay Description:Inhibition of LTA4H (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50575492(CHEMBL4784496)
Affinity DataIC50: 42nMAssay Description:Inhibition of LTA4H in human blood assessed as LTB4 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50575492(CHEMBL4784496)
Affinity DataIC50: 42nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed