BDBM50575349 CHEMBL4860822

SMILES COc1cc(ccc1Cl)-c1cn([C@@H]2C[C@@H](C2)N2CCN(CC2)C(C)=O)c2ncnc(N)c12

InChI Key InChIKey=UNYPIMGHSNYOJD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50575349   

TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575349(CHEMBL4860822)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575349(CHEMBL4860822)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Tel fused KDR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575349(CHEMBL4860822)
Affinity DataIC50: 76nMAssay Description:Inhibition of RET (658 to 1072) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed