BDBM50574357 CHEMBL4855085::US12252491, Example 28

SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1nonc1C(F)(F)F)C1CCC(F)(F)CC1

InChI Key InChIKey=GUYLHVIWYMGYIC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50574357   

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50574357(CHEMBL4855085 | US12252491, Example 28)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574357(CHEMBL4855085 | US12252491, Example 28)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
Go to US Patent