BDBM50574282 CHEMBL4868568

SMILES CCOC(=O)C1=C(NN2CCN(CC(F)(F)F)CC2)O\C(=C/c2c[nH]c3ncccc23)C1=O

InChI Key InChIKey=DNTVXDZWVOVLOD-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50574282   

TargetSerine/threonine-protein kinase pim-1(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 30nMAssay Description:Inhibition of PIM1 (unknown origin) in presence of 1 mM ATP without preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 34nMAssay Description:Inhibition of PIM1 (unknown origin) in presence of 1 mM ATP with preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 212nMAssay Description:Inhibition of CLK1 (unknown origin) in presence of 1 mM ATP without preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 206nMAssay Description:Inhibition of CLK1 (unknown origin) in presence of 1 mM ATP with preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 270nMAssay Description:Inhibition of CLK2 (unknown origin) in presence of 1 mM ATP without preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 227nMAssay Description:Inhibition of CLK2 (unknown origin) in presence of 1 mM ATP with preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 189nMAssay Description:Inhibition of GSK3alpha (unknown origin) in presence of 1 mM ATP without preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 251nMAssay Description:Inhibition of GSK3alpha (unknown origin) in presence of 1 mM ATP with preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 53nMAssay Description:Inhibition of CDC7 in human SW-620 cells assessed as reduction in phosphorylation of MCM2 at Ser53 residue incubated for 48 hrs by Western blot analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50574282(CHEMBL4868568)
Affinity DataIC50: 36nMAssay Description:Inhibition of CDC7 in human SW-620 cells assessed as reduction in phosphorylation of MCM2 at Ser40 residue incubated for 48 hrs by Western blot analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed