BDBM50574277 CHEMBL4871106

SMILES c1cc2c(c(c1)C(=O)N)ncnc2N[C@H](CN3CCC3)c4ccc(c(c4)C(F)(F)F)Cl

InChI Key InChIKey=HXAUJHZZPCBFPN-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50574277   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574277(CHEMBL4871106)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574277(CHEMBL4871106)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed