BDBM50574071 CHEMBL4860183

SMILES CCOC(=O)c1cnc(CCc2c[nH]c3ccccc23)nc1NCCCNC(=S)NCCC(O)=O

InChI Key InChIKey=QTVOPLNICFPHFV-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50574071   

LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate in presence of NAD+ by fluorescence based an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate in presence of NAD+ by fluorescence based an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 5.47E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400 uM NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 5.45E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 200 uM NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 5.92E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 100 uM NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 5.04E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 50 uM NAD+...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 3.22E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using 300 uM Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 3.07E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using 100 uM Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 2.98E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using 33 uM Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using 11 uM Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of recombinant SIRT3 (unknown origin) using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using Ac-Glu-Thr-Asp-Lys(Dec)-AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of recombinant SIRT6 (unknown origin) using Ac-Ile-Arg-Ile-Lys(Su)-AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574071(CHEMBL4860183)
Affinity DataIC50: 3.36E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 800 uM NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed