BDBM50573811 CHEMBL4873553

SMILES FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCNCC3)ncc2Cl)c1

InChI Key InChIKey=XRNBLQBDZUJCOL-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50573811   

TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573811(CHEMBL4873553)
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pretreated for 30 mins followed by substrate addition incubated for 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573811(CHEMBL4873553)
Affinity DataIC50: 55nMAssay Description:Inhibition of human Cathepsin C in human THP-1 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573811(CHEMBL4873553)
Affinity DataIC50: 88nMAssay Description:Inhibition of human Cathepsin C in human U-937 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573811(CHEMBL4873553)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin B (unknown origin) using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573811(CHEMBL4873553)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of Cathepsin L (unknown origin) using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCathepsin S(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573811(CHEMBL4873553)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin S (unknown origin) using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCathepsin K(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573811(CHEMBL4873553)
Affinity DataIC50: 5.62E+3nMAssay Description:Inhibition of Cathepsin K (unknown origin) using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed