BDBM50573801 CHEMBL4859234

SMILES CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1

InChI Key InChIKey=JNAOGJWOQFVLOM-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50573801   

TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pretreated for 30 mins followed by substrate addition incubated for 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 24nMAssay Description:Inhibition of human Cathepsin C in human THP-1 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 21nMAssay Description:Inhibition of human Cathepsin C in human U-937 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin B (unknown origin) using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin L (unknown origin) using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCathepsin S(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin S (unknown origin) using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCathepsin K(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin K (unknown origin) using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of recombinant human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 2.54E+4nMAssay Description:Inhibition of recombinant human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 7.13E+3nMAssay Description:Inhibition of recombinant human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 4.94E+4nMAssay Description:Inhibition of recombinant human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50573801(CHEMBL4859234)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pretreated for 30 mins followed by substrate addition and incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed