BDBM50573423 CHEMBL4870135::US20240190862, Example 5
SMILES COC(=O)\C=C\C(=O)N1CCN([C@@H](C)C1)c1nc(=O)n(-c2c(C)ccnc2C(C)C)c2nc(c(Cl)cc12)-c1ccccc1F
InChI Key InChIKey=PPARMNRYVUWAPD-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50573423
Affinity DataIC50: 95nMAssay Description:Inhibition of GDP-bound KRAS G12C mutant (1 to 169 residues) (unknown origin) assessed as inhibition of SOS-mediated nucleotide exchange pretreated w...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of GDP-bound KRAS G12C mutant (1 to 169 residues) (unknown origin) assessed as inhibition of SOS-mediated nucleotide exchange pretreated w...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in phosphorylated ERK1/2 level incubated for 2 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair