BDBM50573097 CHEMBL4862556

SMILES CCC(=O)CCCCC[C@H](NC(=O)[C@H]1CC11CCN(C)CC1)c1ncc(o1)-c1cc2cccnc2cc1OC

InChI Key InChIKey=JQARXIBZEVLFMI-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50573097   

TargetHistone deacetylase 1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC1 expressed in HEK293F cells incubated for 30 mins by Fluor De Lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC2 expressed in Sf9 cells incubated for 30 mins by Fluor De Lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC3 expressed in HEK293F cells incubated for 30 mins by Fluor De Lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 74nMAssay Description:Inhibition of human HDAC6 incubated for 30 mins by Fluor De Lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human HDAC1 using BML-KI104 as substrate preincubated for 3 hrs followed by substrate addition measured after 60 mins by mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human full length FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 cells using BML-KI104 as substrate preincubated for 3 hrs fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human full length FLAG-tagged HDAC3 expressed in HEK293F cells using BML-KI104 as substrate preincubated for 3 hrs followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 74nMAssay Description:Inhibition of HDAC6 (unknown origin) using BML-KI104 as substrate preincubated for 3 hrs followed by substrate addition measured after 60 mins by mod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of HDAC8 (unknown origin) using BML-KI178 as substrate preincubated for 3 hrs followed by substrate addition measured after 60 mins by mod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50573097(CHEMBL4862556)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed