BDBM50572968 CHEMBL4862851

SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)NCCc1ccccn1

InChI Key InChIKey=GBGTXIJEYNBKMD-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50572968   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50572968(CHEMBL4862851)
Affinity DataIC50: 2.20E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50572968(CHEMBL4862851)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells measured up to 4 hrs at10 mins time ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50572968(CHEMBL4862851)
Affinity DataKi:  8.00E+3nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed