BDBM50572909 CHEMBL4856985
SMILES Cc1coc(n1)-c1cn([C@@H]2O[C@H](COc3ccc4ccc(nc4c3)N3CCC3)[C@@H](O)[C@@H]2F)c2ncnc(N)c12
InChI Key InChIKey=LSEFEXOHUPJOTB-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50572909
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of METTL3 (unknown origin) using 3' biotinylated RNA (UCUGGACUAAA) and 3H-SAM as a substrate preincubated for 5 mins followed by substrate...More data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of METTL3-mediated m6A methylation in human MOLM-3 cells assessed as reduction in mRNA level measured after 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of METTL3 in human MOLM-13 cells assessed as decrease in cellular m6A mRNA level incubated for 24 hrs by NanoDrop spectrophotometer based ...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sapienza University of Rome
Curated by ChEMBL
Sapienza University of Rome
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of METTL3/METTL14 (unknown origin) using biotinylated RNA (UCUGGACUAAA-biotin) and 3H-SAM as substrate preincubated for 5 mins followed by...More data for this Ligand-Target Pair