BDBM50572907 CHEMBL4850503

SMILES CCNc1ccc2ccc(OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cc(C4CCCC4)c4c(N)ncnc34)cc2n1

InChI Key InChIKey=BQSAJTFFAAGPLU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572907   

TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50572907(CHEMBL4850503)
Affinity DataIC50: 10nMAssay Description:Inhibition of METTL3 (unknown origin) using 3' biotinylated RNA (UCUGGACUAAA) and 3H-SAM as a substrate preincubated for 5 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50572907(CHEMBL4850503)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of METTL3-mediated m6A methylation in human MOLM-3 cells assessed as reduction in mRNA level measured after 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed