BDBM50572787 CHEMBL4860876

SMILES O=C([C@H]1Cc2ccccc2C(=O)O1)N1CCN(Cc2nc3sc4CCCCc4c3c(=O)[nH]2)CC1

InChI Key InChIKey=ZJOXWRFJOUWUKX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50572787   

TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572787(CHEMBL4860876)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572787(CHEMBL4860876)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of human NSD2 SET domain-mediated H3K36 methylation using histone H3 as substrate by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572787(CHEMBL4860876)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of human NSD2 SET domain-mediated H3K36 methylation using histone H3 as substrate by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50572787(CHEMBL4860876)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572787(CHEMBL4860876)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of human NSD2 SET domain using histone H3 as substrate assessed as reduction in H3K36 methylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572787(CHEMBL4860876)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of NSD2 (unknown origin) using H3K36 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed