BDBM50572706 CHEMBL4855370

SMILES CN(Cc1ccccc1C(F)(F)F)S(=O)(=O)N1CCc2cc(ccc2C1)N1CCN(CC1)C(C)=O

InChI Key InChIKey=FCXQRWNSSFAJRQ-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50572706   

TargetNuclear receptor ROR-gamma(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50572706(CHEMBL4855370)
Affinity DataEC50:  670nMAssay Description:Agonist activity at human RORgammat LBD expressed in HEK293T cells incubated for 16 to 20 hrs by Gal4-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50572706(CHEMBL4855370)
Affinity DataEC50:  97nMAssay Description:Agonist activity at europium-labeled human RORgammat LBD assessed as induction of XL665-labeled co-activator SRC1 recruitment incubated for 1 hr by d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50572706(CHEMBL4855370)
Affinity DataEC50:  1.12E+3nMAssay Description:Agonist activity at RORgammat in C57 mouse CD4+ T cells cells assessed as induction of Th17 cells differentiation by measuring increase in IL17 produ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed