BDBM50572638 CHEMBL4873077

SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1

InChI Key InChIKey=RTVAJYMKSUWXID-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50572638   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50572638(CHEMBL4873077)
Affinity DataEC50:  90nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50572638(CHEMBL4873077)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human ERG channel expressed in CHO cells measured after 7 to 10 mins at -80 mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50572638(CHEMBL4873077)
Affinity DataEC50:  710nMAssay Description:Positive allosteric modulation of human alpha7 nAChR expressed in HEK293 cells assessed as increase in peak current amplitude measured after 6 to 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed