BDBM50572432 CHEMBL4846288

SMILES COc1ccc(Nc2cc(NCCc3nnc(s3)C(C)C)ncn2)c(OC)c1

InChI Key InChIKey=JGYZWQHYUTULEQ-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572432   

TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50572432(CHEMBL4846288)Copy SMILESCopy InChI

Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in A2780/ADR cells preincubated for 30 mins followed by calcein AM addition and measured at 60 secs ti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/22/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50572432(CHEMBL4846288)Copy SMILESCopy InChI

Affinity DataIC50: 8.11E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in MDCK2-BCRP cells assessed as reduction in pheophorbide A accumulation measured after 120 mins by fl...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/22/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL