BDBM50572209 CHEMBL4858977

SMILES OC(=O)c1cc(F)c2nc(sc2c1)N1CC2C(C1)C2\C=C\c1c(onc1-c1c(Cl)cccc1Cl)C1CC1

InChI Key InChIKey=PSVYKLYOBSFTMT-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572209   

TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572209(CHEMBL4858977)
Affinity DataEC50:  120nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572209(CHEMBL4858977)
Affinity DataEC50:  609nMAssay Description:Agonist activity at His-tagged human FXR LBD assessed as induction of coactivator SRC-1 peptide recruitment measured after 30 mins by plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed