BDBM50572098 CHEMBL4854815::US20260109697, Compound A32

SMILES COc1ccn2c(cnc2c1)-c1cc(NCc2ccc(cc2)-c2cnn(C)n2)ncn1

InChI Key InChIKey=LZUOWTDXXDSWJF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50572098   

TargetMast/stem cell growth factor receptor Kit(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572098BDBM50572098(CHEMBL4854815 | US20260109697, Compound A32)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant C-KIT V654A mutant (544 to end residues) using GGMEDIYEFMGGKKK as substrate measured after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit [V654A](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 50572098BDBM50572098(CHEMBL4854815 | US20260109697, Compound A32)
Affinity DataIC50: 4.40nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572098BDBM50572098(CHEMBL4854815 | US20260109697, Compound A32)
Affinity DataIC50: 78nMAssay Description:Inhibition of KIT (delta 560 to 576 residues) deletion/V654A double mutant autophosphorylation at Y703 in human GIST-430/654 harboring KIT (delta560 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed