BDBM50571550 CHEMBL4867046

SMILES COc1ccc(CCc2nc3cc(ccn3c2NC2CCCCC2)-c2c(C)noc2C)cc1

InChI Key InChIKey=DKCFKYUXDNTZAE-UHFFFAOYSA-N

Data  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50571550   

TargetCREB-binding protein(Human)
University of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571550(CHEMBL4867046)
Affinity DataIC50: 159nMAssay Description:Inhibition of His-tagged CBP (unknown origin) using biotinylated-H3K56ac peptide as substrate incubated for 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571550(CHEMBL4867046)
Affinity DataIC50: 6.59E+3nMAssay Description:Inhibition of His-tagged BRD4 BD1 (unknown origin) using biotinylated-JQ1 peptide as substrate incubated for 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571550(CHEMBL4867046)
Affinity DataKd:  265nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BromoELECT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
University of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571550(CHEMBL4867046)
Affinity DataKd:  285nMAssay Description:Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BromoELECT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571550(CHEMBL4867046)
Affinity DataKd:  9.20E+3nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system by BromoELEC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed