BDBM50571033 CHEMBL4876326::US12415803, Example 137

SMILES Cc1c(-c2nc3c(-c4ccc5c(c4)CCC[C@H]5NC(=O)c4nc(C(C)(C)C)no4)ccnc3[nH]2)cnn1C1CCOCC1

InChI Key InChIKey=IWJJKWNPIYKQNB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50571033   

TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571033BDBM50571033(CHEMBL4876326 | US12415803, Example 137)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571033BDBM50571033(CHEMBL4876326 | US12415803, Example 137)
Affinity DataIC50: 1nMAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571033BDBM50571033(CHEMBL4876326 | US12415803, Example 137)
Affinity DataIC50: 30nMAssay Description:Inhibition of BTK in human PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed