BDBM50570970 CHEMBL4858598

SMILES CNc1ncc(cc1C(=O)NC(C)C)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C

InChI Key InChIKey=RLQQJEXTCSZPIW-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50570970   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Hibercell

Curated by ChEMBL

LigandBDBM50570970(CHEMBL4858598)Copy SMILESCopy InChI

Affinity DataIC50: 129nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetEukaryotic translation initiation factor 2 subunit 1(Human)
Hibercell

Curated by ChEMBL

LigandBDBM50570970(CHEMBL4858598)Copy SMILESCopy InChI

Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL