BDBM50570946 CHEMBL4853233

SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)Nc2ccccc2)cc1C

InChI Key InChIKey=VKFZHZWJYKJRRR-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50570946   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Hibercell

Curated by ChEMBL

LigandBDBM50570946(CHEMBL4853233)Copy SMILESCopy InChI

Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy Entry DOIPubMed
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TargetEukaryotic translation initiation factor 2 subunit 1(Human)
Hibercell

Curated by ChEMBL

LigandBDBM50570946(CHEMBL4853233)Copy SMILESCopy InChI

Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL