BDBM50569791 CHEMBL4846828

SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CC[C@@H](CC(=O)C=C)C4)c([nH]c1=O)c23

InChI Key InChIKey=VHODWDDAHBRXHH-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50569791   

TargetTyrosine-protein kinase BTK(Mouse)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50569791(CHEMBL4846828)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of BTK in C57Bl/6 mouse splenocyte assessed as reduction in anti-IgM-induced CD69 expression incubated for 1 hr followed anti-IgM stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50569791(CHEMBL4846828)
Affinity DataKi:  12nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed