BDBM50569655 CHEMBL4869836::US11802133, Example 279

SMILES [H][C@@]12CN(CC[C@]1([H])OCC(=O)N2)C(=O)N1CC(CCc2ccc(cc2F)C(F)(F)F)C1

InChI Key InChIKey=LULFUMCUGHSWTN-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50569655   

TargetMonoglyceride lipase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50569655(CHEMBL4869836 | US11802133, Example 279)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant MAGL (unknown origin) using 4-Nitrophenlyacetate as substrate incubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50569655(CHEMBL4869836 | US11802133, Example 279)
Affinity DataIC50: 1nMAssay Description:The 4-NPA assay was carried out in 384 well assay plates (black with clear bottom, non-binding surface treated, Corning Ref. 3655) in a total volume ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Mouse)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50569655(CHEMBL4869836 | US11802133, Example 279)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50569655(CHEMBL4869836 | US11802133, Example 279)
Affinity DataKd:  6.10nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed