BDBM50569523 CHEMBL4846686::US11452717, Compound TableB-2.190

SMILES O=C(NCc1ccncc1)Nc1ccc(cc1)S(=O)(=O)N1CC2CCC(C1)O2

InChI Key InChIKey=KTSOHNHLOLGQCY-UHFFFAOYSA-N

Data  1 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50569523   

TargetNicotinamide phosphoribosyltransferase(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569523(CHEMBL4846686 | US11452717, Compound TableB-2.190)
Affinity DataEC50:  279nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569523(CHEMBL4846686 | US11452717, Compound TableB-2.190)
Affinity DataEC50:  1.05E+3nMAssay Description:NAMPT reaction was performed in 50 mM HEPES, pH 7.5, containing 5 mM MgCl2, 0.1% Prionex, 0.005% Tween 20, and 1 mM TCEP at room temperature in Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569523(CHEMBL4846686 | US11452717, Compound TableB-2.190)
Affinity DataEC50:  370nMAssay Description:Activation of N-terminal His-tagged human NAMPT-mediated NMN production expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569523(CHEMBL4846686 | US11452717, Compound TableB-2.190)
Affinity DataKd:  6.82E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed