BDBM50569187 CHEMBL4861646

SMILES O=S1(=O)CC2(OCCO2)c2cc3nccc(Nc4ccc5scnc5c4)c3cc12

InChI Key InChIKey=BGDMMVIAARSUKG-UHFFFAOYSA-N

Data  8 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50569187   

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to human wild type RIPK3 (M1/Q307) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataKd:  5.95E+3nMAssay Description:Binding affinity to human wild type RIPK1 (M1/K305) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 152nMAssay Description:Inhibition of PDGFRA (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK4/Cyclin D3 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetActivin receptor type-1B(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 3.74E+3nMAssay Description:Inhibition of human ALK4 using ATP as substrate incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of BRAF (unknown origin) in presence of ATP by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTOR (unknown origin) using ATP as substrate after 60 mins by Lance ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 7.77E+3nMAssay Description:Inhibition of human PI3Kalpha using ATP as substrate at 25 uM incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by QPatch - automated patch-clamp technologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed