BDBM50568725 CHEMBL4873935::US12258342, Example 1

SMILES Cc1[nH]c(C(=O)Nc2nc3ccc(cc3s2)C(O)=O)c(Cl)c1Cl

InChI Key InChIKey=GEZPDKBNSBNCLH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50568725   

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568725(CHEMBL4873935 | US12258342, Example 1)
Affinity DataIC50: 13nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568725(CHEMBL4873935 | US12258342, Example 1)
Affinity DataIC50: 72nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568725(CHEMBL4873935 | US12258342, Example 1)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568725(CHEMBL4873935 | US12258342, Example 1)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of Escherichia coli DNA gyrase incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568725(CHEMBL4873935 | US12258342, Example 1)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2025
Entry Details
Go to US Patent