BDBM50568719 CHEMBL4866508::US12258342, Example 41

SMILES CC(C)N(C(=O)c1[nH]c(C)c(Cl)c1Cl)c1nc2ccc(cc2s1)C(O)=O

InChI Key InChIKey=VIVDPWOYADDJAN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50568719   

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568719(CHEMBL4866508 | US12258342, Example 41)
Affinity DataIC50: 320nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568719(CHEMBL4866508 | US12258342, Example 41)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568719(CHEMBL4866508 | US12258342, Example 41)
Affinity DataIC50: 320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2025
Entry Details
Go to US Patent