BDBM50568614 CHEMBL4849795

SMILES Nc1nc(Cc2ccccc2)cn2c3ccccc3nc12

InChI Key InChIKey=NULDMQXOPYHTEN-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50568614   

TargetAdenosine receptor A2a(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50568614(CHEMBL4849795)
Affinity DataIC50: 9.20nMAssay Description:Binding affinity to recombinant human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50568614(CHEMBL4849795)
Affinity DataIC50: 9.20nMAssay Description:Displacement of [3H]-ZM241385 from human recombinant A2A receptor expressed in human HEK293 cell membrane preincubated for 5 mins and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50568614(CHEMBL4849795)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at recombinant human adenosine A2A receptor expressed in HEK293 cells measured by cAMP functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50568614(CHEMBL4849795)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at human A2A expressed in human HEK293 cells assessed as reduction in cAMP production preincubated for 10 mins followed by NECA s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50568614(CHEMBL4849795)
Affinity DataEC50:  165nMAssay Description:Antagonist activity at human A2A receptor on T-cells assessed as increase of IL-2 production preincubated for 1 hr followed by addition of T-cell act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50568614(CHEMBL4849795)
Affinity DataIC50: 733nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO-K1 cell membrane preincubated for 5 mins followed measured after 50 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed