BDBM50568522 CHEMBL4864352

SMILES CN1CCN(CC1)C(=O)CNC1CC1c1cc(F)cc(F)c1OCc1ccccc1

InChI Key InChIKey=GNKCLVXPAGTZSF-UHFFFAOYSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50568522   

TargetLysine-specific histone demethylase 1A(Human)
Riken Center For Sustainable Resource Science

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataIC50: 870nMAssay Description:Inhibition of human LSD1 assessed as demethylase activity of LSD1 using Histone H3(1-20)K4me2 peptide as substrate incubated for 10 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Center For Sustainable Resource Science

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataIC50: 870nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Center For Sustainable Resource Science

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi:  370nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) using Lys4-dimethylated H3 (1-20) peptide as substrate incubated for 30 mins by peroxidase-coupled ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Center For Sustainable Resource Science

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi:  370nMAssay Description:Inhibition of LSD1 (unknown origin) assessed as inhibition constant by peroxidase-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Center For Sustainable Resource Science

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi:  750nMAssay Description:Inhibition of human LSD1 assessed as inhibitory constant using Histone H3(1-20)K4me2 peptide as substrate incubated for 10 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 2(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi: >2.50E+5nMAssay Description:Inhibition of LSD2 (unknown origin) using Lys4-dimethylated H3 (1-20) peptide as substrate incubated for 30 mins by peroxidase-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi: >2.50E+5nMAssay Description:Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells using tyramine as substrate incubated for 30 mins by peroxidase-coupled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi: >2.50E+5nMAssay Description:Inhibition of human MAO-B expressed in expressed in baculovirus infected BTI insect cells using tyramine as substrate incubated for 30 mins by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi: >2.50E+5nMAssay Description:Inhibition of MAO-A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 2(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi: >2.50E+5nMAssay Description:Inhibition of LSD2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi: >2.50E+5nMAssay Description:Inhibition of MAO-B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed