BDBM50568138 CHEMBL4854735

SMILES Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1

InChI Key InChIKey=ALYSSPGOUMAGSF-UHFFFAOYSA-N

Data  1 KI  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50568138   

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Nav1.5 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of late channel current at holding potential of -95 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 18nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of peak channel current at holding potential of -95 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 270nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 560nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 44nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Nav1.6 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Nav1.2 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 90nMAssay Description:Inhibition of human Nav1.1 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 65nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 220nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by sodium flux analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 230nMAssay Description:Inhibition of human Nav1.6 by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 270nMAssay Description:Inhibition of human Nav1.2 by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 620nMAssay Description:Inhibition of human Nav1.1 by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 39nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 65nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataKi:  370nMAssay Description:Displacement of [3H]BNZA from Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed