BDBM50568110 CHEMBL4865383::US11851436, Compound A1-11

SMILES Oc1ccc(cc1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12

InChI Key InChIKey=REIKFAGJACMEBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50568110   

TargetRibosomal protein S6 kinase alpha-3(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568110(CHEMBL4865383 | US11851436, Compound A1-11)
Affinity DataIC50: 82nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568110(CHEMBL4865383 | US11851436, Compound A1-11)
Affinity DataIC50: 25.7nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2024
Entry Details
Go to US Patent