BDBM50568104 CHEMBL4858257::US11851436, Compound A1-2

SMILES CC(C)CCn1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12

InChI Key InChIKey=OYTSXCFOGSTFSE-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50568104   

TargetRibosomal protein S6 kinase alpha-3(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568104(CHEMBL4858257 | US11851436, Compound A1-2)
Affinity DataIC50: 56nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568104(CHEMBL4858257 | US11851436, Compound A1-2)
Affinity DataEC50:  970nMAssay Description:Inhibition of RSK2 in human MOLM-13 assessed as reduction in cell viability measured after 72 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568104(CHEMBL4858257 | US11851436, Compound A1-2)
Affinity DataIC50: 24.6nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2024
Entry Details
Go to US Patent