BDBM50567724 CHEMBL4877407

SMILES Nc1cc(Cc2ccn(Cc3cccc(O[C@H]4CCNC4)c3)n2)c2nn[nH]c2n1

InChI Key InChIKey=ZVZNFFSLPNDHRU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50567724   

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567724(CHEMBL4877407)
Affinity DataIC50: 46nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetThyroid peroxidase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567724(CHEMBL4877407)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567724(CHEMBL4877407)
Affinity DataIC50: 1.30E+4nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) measured at 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed