BDBM50567580 CHEMBL4845880

SMILES OC1N(CC2(O)CCN(CC2)C(=O)CCc2ccccc2)C=Nc2cc(NCCN3CCCC3)ccc12

InChI Key InChIKey=ACTVSSBKQMEALS-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50567580   

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50567580(CHEMBL4845880)
Affinity DataIC50: 4.86E+3nMAssay Description:Inhibition of recombinant USP7 catalytic domain (unknown origin) using UbA10 as substrate incubated with substrate for 75 mins followed by compound a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50567580(CHEMBL4845880)
Affinity DataIC50: 5.05E+3nMAssay Description:Inhibition of N-terminal His-FLAG-tagged human USP7 (2 to 1102 residues) expressed in baculovirus infected Sf9 cells using Ub-AMC as substrate preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50567580(CHEMBL4845880)
Affinity DataKd:  7.70E+4nMAssay Description:Binding affinity to recombinant USP7 (208 to 560 residues) (unknown origin) assessed as dissociation constant by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed