BDBM50567047 CHEMBL4848254
SMILES CN(C)c1nccc(n1)-c1cnn2ncccc12
InChI Key InChIKey=IFLBFWBMAWIBBZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50567047
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Perha Pharmaceuticals
Curated by ChEMBL
Perha Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 236nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of human DYRK1A-mediated tau phosphorylation expressed in HEK293 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Perha Pharmaceuticals
Curated by ChEMBL
Perha Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 9.67E+3nMAssay Description:Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...More data for this Ligand-Target Pair
Affinity DataIC50: 319nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
Affinity DataIC50: 2.97E+3nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
Affinity DataIC50: 219nMAssay Description:Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataIC50: 464nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of full length GST-tagged human DYRK1A phosphorylation expressed in baculovirus expression system in presence of [gamma-33P]ATP by radiome...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Perha Pharmaceuticals
Curated by ChEMBL
Perha Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3.27E+3nMAssay Description:Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Perha Pharmaceuticals
Curated by ChEMBL
Perha Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.45E+3nMAssay Description:Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Human)
Perha Pharmaceuticals
Curated by ChEMBL
Perha Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 9.59E+3nMAssay Description:Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKd: 0.240nMAssay Description:Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 5.40nMAssay Description:Binding affinity to human CLK1 assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Displacement of Kinase tracer 236 from biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by TR-FRET...More data for this Ligand-Target Pair
Affinity DataKd: 1.00E+4nMAssay Description:Binding affinity to wild-type human partial length WNK2 (V47 to D482 residues) expressed in mammalian expression system measured after 1 hr by compet...More data for this Ligand-Target Pair
TargetSTE20/SPS1-related proline-alanine-rich protein kinase(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKd: 1.00E+4nMAssay Description:Binding affinity to wild-type human partial length STK39 (P43 to I357 residues) expressed in mammalian expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
Affinity DataKd: 1.80E+3nMAssay Description:Binding affinity to wild-type human partial length JAK3 JH1 catalytic domain (I781 to S1124 residues) expressed in mammalian expression system measur...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1B(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKd: 1.00E+4nMAssay Description:Binding affinity to wild-type human partial length CAMK1B (W9 to A311 residues) expressed in mammalian expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKd: 1.80E+3nMAssay Description:Binding affinity to wild-type human partial length MKNK2 (G63 to S388 residues) expressed in mammalian expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
Affinity DataKd: 1.20E+3nMAssay Description:Binding affinity to wild-type human partial length HIPK2 (M153 to S564 residues) expressed in mammalian expression system measured after 1 hr by comp...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Perha Pharmaceuticals
Curated by ChEMBL
Perha Pharmaceuticals
Curated by ChEMBL
Affinity DataKd: 360nMAssay Description:Binding affinity to wild-type human full length DYRK2 (M1 to S528 residues) expressed in mammalian expression system measured after 1 hr by competiti...More data for this Ligand-Target Pair
Affinity DataKd: 220nMAssay Description:Binding affinity to wild-type human partial length CLK2 (D144 to R498 residues) expressed in bacterial expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
Affinity DataKd: 70nMAssay Description:Binding affinity to wild-type human full length CLK1 (M1 to I484 residues) expressed in bacterial expression system measured after 1 hr by competitiv...More data for this Ligand-Target Pair
Affinity DataKd: 61nMAssay Description:Binding affinity to wild-type human partial length CLK4 (R135 to K481 residues) expressed in bacterial expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Perha Pharmaceuticals
Curated by ChEMBL
Perha Pharmaceuticals
Curated by ChEMBL
Affinity DataKd: 56nMAssay Description:Binding affinity to wild-type human full length DYRK1B (M1 to S629 residues) expressed in bacterial expression system measured after 1 hr by competit...More data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Binding affinity to wild-type human partial length HASPIN (I452 to K798 residues) expressed in mammalian expression system measured after 1 hr by com...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKd: 3nMAssay Description:Binding affinity to wild-type human partial length DYRK1A (H129 to S509 residues) expressed in mammalian expression system measured after 1 hr by com...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKd: 85nMAssay Description:Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured up to 5 ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKon: 0.240M-1s-1Assay Description:Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation rate constant measured up ...More data for this Ligand-Target Pair