BDBM50566316 CHEMBL4859858

SMILES [H][C@@]12C[C@@H]([C@@H](CC)CN1CCc1c2[nH]c2cccc(OC)c12)C(=C/OC)\C(=O)OC

InChI Key InChIKey=LELBFTMXCIIKKX-UHFFFAOYSA-N

Data  14 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50566316   

TargetMu-type opioid receptor(Mouse)
University of Health Sciences & Pharmacy and Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataEC50:  6.23E+3nMAssay Description:Agonist activity at mouse MOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 60 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of MOP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DOP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KOP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]8-OH-DAPT from human recombinant 5-HT1A receptor expressed in HEK cells measured after 60 to 90 mins by radioligand completion as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  96nMAssay Description:Displacement of [3H]8-OH-DAPT from human recombinant 5-HT1A receptor expressed in CHO cells measured after 60 to 90 mins by radioligand completion as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  108nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
University of Health Sciences & Pharmacy and Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  578nMAssay Description:Displacement of [125]IBNtxA from mouse MOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  728nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  728nMAssay Description:Binding affinity to MOP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  1.32E+3nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT2A receptor expressed in HEK cells by radioligand completion assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Mouse)
University of Health Sciences & Pharmacy and Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [125]IBNtxA from mouse KOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity to KOP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  5.43E+3nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT2C receptor expressed in HEK cells by radioligand completion assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Health Sciences & Pharmacy and Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi:  7.95E+3nMAssay Description:Displacement of [125]IBNtxA from mouse DOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50566316(CHEMBL4859858)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to DOP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed