BDBM50566206 CHEMBL4786599

SMILES C[C@H](Cc1ccc(F)cc1)NC(=O)c1ccc2NC(=O)\C(=C/c3[nH]c(C)c(NC(=O)CCl)c3C)c2c1

InChI Key InChIKey=UZDAXRRQYZMQGI-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50566206   

TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50566206(CHEMBL4786599)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50566206(CHEMBL4786599)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of bovine GRK2 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50566206(CHEMBL4786599)
Affinity DataKi:  19nMAssay Description:Covalent inhibition of GRK5 (unknown origin) using porcine brain tubulin as substrate by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed