BDBM50566150 CHEMBL4781687

SMILES CC1CCN(CC1)c1nc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)ccc12)C(F)(F)F

InChI Key InChIKey=DPMRJPMKHJGTMZ-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50566150   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50566150(CHEMBL4781687)
Affinity DataIC50: 0.270nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK cells assessed as inhibition of 10 nM capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50566150(CHEMBL4781687)
Affinity DataIC50: 0.270nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin induced intracellular Ca2+ ions by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50566150(CHEMBL4781687)
Affinity DataKi:  0.720nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50566150(CHEMBL4781687)
Affinity DataKi:  3.90nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of 30 nM capsaicin-induced calcium uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed