BDBM50565875 CHEMBL4793361

SMILES CCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cccc2ccccc12)C(O)=O

InChI Key InChIKey=WFURAPCVZMOPKL-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50565875   

TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50565875(CHEMBL4793361)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293T cells co-expressing PDZ-Rho-Gef-RLucll assessed as induction of Galpha12 effector (PDZ-Rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50565875(CHEMBL4793361)
Affinity DataEC50:  123nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293 cells co-expressing Rlucll-beta-arrestin2 assessed as induction of beta-arrestin2 recruitm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50565875(CHEMBL4793361)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293 cells co-expressing Galpha(i1)-RlucII(91) assessed as induction of dissociation of Galpha(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50565875(CHEMBL4793361)
Affinity DataKi:  13nMAssay Description:Displacement of [125I] [NIe75, Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed