BDBM50565802 CHEMBL4165444::US11584714, Compound 29

SMILES O=[#6]1-[#7]-[#6](=S)-[#7]-[#6](=O)\[#6]-1=[#6]\[#6]=[#6]\c1ccco1

InChI Key InChIKey=JMNAHTIUMGIBRE-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50565802   

TargetDNA repair protein RAD52 homolog(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565802(CHEMBL4165444 | US11584714, Compound 29)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM50565802(CHEMBL4165444 | US11584714, Compound 29)
Affinity DataKi: <1.00E+3nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetProthrombin(Human)
Omeros

US Patent
LigandPNGBDBM50565802(CHEMBL4165444 | US11584714, Compound 29)
Affinity DataKi:  6.25E+4nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent