BDBM50564614 CHEMBL4797329

SMILES OC1(CCC(F)(F)CC1)c1cc(Nc2cc(Oc3cn(nc3C3CC(F)(F)C3)C3CC3)ccn2)ccn1

InChI Key InChIKey=JJZBAWFKKKWSHN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50564614   

TargetTGF-beta receptor type-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50564614(CHEMBL4797329)
Affinity DataIC50: 28nMAssay Description:Inhibition of ALK5 (unknown origin) measured after 120 mins of incubation by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50564614(CHEMBL4797329)
Affinity DataIC50: 57nMAssay Description:Inhibition of TGF-beta type 1 receptor in mouse NIH3T3 cells expressing Luc-Smad 2/3 measured after 24 hrs incubation by cell based Bright-Glo Lucife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed