BDBM50564157 CHEMBL4792963::US20250026741, Compound #10

SMILES OC(=O)c1cc(ccc1O)-c1ccc(\C=C2/Sc3ccccc3C2=O)o1

InChI Key InChIKey=SEYBOOOGSOESAD-UHFFFAOYSA-N

Data  1 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50564157   

TargetDual specificity protein phosphatase 3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of VHR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 5(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of N-terminal His-tagged striatal-enriched protein tyrosine phosphatase (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of LYP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 2.87E+4nMAssay Description:Inhibition of HEPTP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetProtein phosphatase 1B(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 1.53E+5nMAssay Description:Inhibition of PPM1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetProtein phosphatase 1G(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 1.67E+5nMAssay Description:Inhibition of PPM1G (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase O(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 2.14E+5nMAssay Description:Inhibition of GLEEP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 1.05E+4nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 1.05E+4nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [248-527](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataIC50: 1.05E+4nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 5(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50564157(CHEMBL4792963 | US20250026741, Compound #10)
Affinity DataKi:  3.70E+3nMAssay Description:Competitive inhibition of N-terminal His-tagged striatal-enriched protein tyrosine phosphatase (unknown origin) assessed as inhibition of p-nitrophen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed