BDBM50563900 CHEMBL4784865

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4NCCOc34)c(F)c2)no1

InChI Key InChIKey=WUZHXUJHAINKRH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50563900   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50563900(CHEMBL4784865)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human RET V804L mutant using KKKVSRSGLYRSP as substrate incubated for 15 mins followed by Mg/ATP addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50563900(CHEMBL4784865)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human RET V804M mutant using KKKVSRSGLYRSP as substrate incubated for 15 mins followed by Mg/ATP addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50563900(CHEMBL4784865)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human RET using KKKSPGEYVNIEFG as substrate incubated for 15 mins followed by Mg/ATP addition and measured after 40 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed