BDBM50563734 CHEMBL4747653::US11453681, Compound C21

SMILES Cc1c2NCCOc2ncc1-c1ccc2NC(=O)\C(=C/c3cc(c[nH]3)C#N)c2c1

InChI Key InChIKey=YYOIGXHMRKRQCY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50563734   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50563734(CHEMBL4747653 | US11453681, Compound C21)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of recombinant human HPK1 expressed in baculovirus infected insect cells using SRKS1 peptide as substrate incubated for 15 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50563734(CHEMBL4747653 | US11453681, Compound C21)
Affinity DataIC50: 0.0700nMAssay Description:The enzymatic activity of human HPK1 (MAP4K1) was monitored in a biochemical assay in the presence or absence of compounds and using a synthetic pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent